The terms meaning and purpose often appear together, and I would frame their relationship this way: when we act with purpose, we take actions that are important enough to lend meaning to our lives. Meaningful actions are always in accord with our personal life values, whether we value accomplishment, wellbeing, comfort and safety, healthy relationships, artistic expression, or any other quality of life. Living purposefully, engaged in an active search for meaning, is a highly beneficial mastery and wellbeing practice that can have a profound positive impact on physical and emotional health. It is particularly effective in alleviating depression.