Controlling for all confounding variables, researchers have found that people who live their lives with mastery, that is, taking charge of their lives, making conscious choices, and dealing with disappointments and tragedy as challenges rather than as defeats, are healthier than those who allow themselves to feel defeated. The most evidence-based of these mastery behaviors can be learned and practiced. Making a commitment to living with intentionality and making these mindfulness-based practices part of daily life leads to living with greater mastery & wellbeing, which then increases the odds of experiencing improved health. This is due to reductions in emotional distress and physiological stress. It is also due to the fact that living with mastery and intentionality improve immune function. This has been evidenced by psychoneuroimmunology research.